Hereby, PD-L1 promoter methylation was shown to correlate/associate with the prognostic variables age (p = 0.028), pathological tumor category (pT) (p < 0.001), the International Society of Urological Pathology (ISUP) grading group (p = 0.001), surgical margin (p = 0.013), and ETS-related gene (ERG) expression (p = 0.022, Table 2). This evidence concerns the gene CD274 and neoplasm.