EGFR and non-small cell lung carcinoma: So far, various clinical trials of OSI are being conducted, such as the therapeutic effects of OSI versus gefitinib or erlotinib in EGFR-TKI sensitive mutation of naive NSCLC patients [14] and the comparison of OSI with doublet chemotherapy (carboplatin and pemetrexed) as second-line therapy strategy for patients with advanced EGFR T790M NSCLC patients [15].