Since the activation of Wnt/β-catenin and EGF/Ras-MAPK signaling is not always clear in lung and tongue SCCs compared with colon cancers and lung adenocarcinomas, ARL4C might function as an oncogene in a certain types of cancers in which growth factor signaling is not constitutively activated. The gene discussed is ARL4C; the disease is tongue squamous cell carcinoma.