ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Chronic myelogenous leukemia (CML), a myeloproliferative disorder caused by the BCR-ABL1 oncoprotein, is an ideal model to dissect COX2-dependent and COX2-independent mechanisms of celecoxib growth inhibition because the role of many signal transduction pathways in CML cell proliferation and survival is well established, allowing the effects of celecoxib to be linked to the modulation of specific BCR-ABL-regulated pathways.