Since our previous findings in SCC of the vulva [2] hint at a similar expression correlation as that detected in lung cancer, we decided to quantify the expression levels of HMGA2 and miR-30c in the 10 tumors of the vulva that were found to have deregulated HMGA2 and FHIT, and to assess the expression levels of the miRNA let-7a which is known to target and repress HMGA2 [9–11], as well as the expression of the let-7a regulators LIN28A and LIN28B [12]. This evidence concerns the gene HMGA2 and vulvar neoplasm.