Next, we assessed the effects of NGF/NGFRs on the expression of several downstream target genes related WNT/β-catenin, such as cluster of differentiation 44 (CD44), cellular homologue of avian myelocytomatosis virus oncogene (C-myc), matrix metalloproteinase 2 (MMP2), matrix metalloproteinase 7(MMP7) and tissue inhibitors of metalloproteinase 2 (TIMP2), which had revealed significant changes in ovarian cancer cells, and the inhibition of NGF, TrkA or P75 can reverse their expressions. Here, TIMP2 is linked to ovarian cancer.