To further identify the regulation effects of NGF/NGFRs on WNT/β-catenin pathways in ovarian cancer cells, we examined the expression changes of WNT/β-catenin downstream target genes that are related to tumor proliferation, adhesion, invasion and metastasis, such as CD44, C-myc, MMP2, MMP7 and TIMP2, following the stimulation with 100 ng/ml NGF, 10 uM Ro 08-2750, 100 uM K252a, 5 nM LM11A-31 and 100 uM K252a+5 nM LM11A-31, and sustained for 24 hour period of observation. The gene discussed is MMP2; the disease is ovarian cancer.