APC and colorectal carcinoma: Stabilization of mutant K-Ras protein (MT-K-Ras) in CRC cells harboring both APC and K-Ras mutations results in liver metastasis with cancer stem cell activation via strong secondary activation of the Wnt/β-catenin signaling through the MEK-ERK pathway in addition to the initial activation by APC loss [9, 10].