Although growth inhibition by KY1022 was significant in SW480 and LoVo cells harboring APC and K-Ras mutations, we only observed weak growth inhibitory effect of KY1022 on normal colonic fibroblast CCD18-CO and HEK293 cells (Supplementary Figure S4), indicating a specific or at least preferential effect of KY1022 in the suppression of CRC cells specifically harboring APC and K-Ras mutations. The gene discussed is APC; the disease is colorectal carcinoma.