CDH1 and small intestine neoplasm: Aberrant Wnt/β-catenin and Ras signaling decrease E-cadherin expression, a hallmark of epithelial-mesenchymal transition (EMT), conferring cell motility and invasiveness [12–14], and synergistically increases the invasion capacity of small intestinal tumors in mice harboring the APC and K-Ras mutations [6].