KRAS and colorectal carcinoma: KY1022 inhibited the activities of the Ras downstream kinases ERK and Akt in HEK293 cells transiently expressing WT K-Ras or MT K-RasG12D (Supplementary Figure S3A) as well as in SW480 and LoVo human CRC cell lines harboring K-RasG12V and K-RasG13D, respectively (Supplementary Figure S3B).