BCL2 and chondrosarcoma: Once mitochondrial dysfunction occurred, ACDB increased protein levels of Bak (12.9 fold), Bid (4.23 fold) and Bax (1.92 fold) and decrease Bcl-XL (0.24 fold) and Bcl-2 (0.45 fold) protein expression in response to chondrosarcoma cell apoptosis (Figure 3C).