EZH2 and Familial prostate cancer: An increased EZH2 expression in normal prostatic epithelial cells can suppress DAB2IP gene expression [28], DAB2IP was predicted as target in 14 cell lines including abl and LNCaP cell lines and was significantly correlated with EZH2 (Coef= -0.38, P<0.05) in RNA sequencing data in 497 prostate cancer patients (Supplementary Tables S1 and S3).