EZH2 and Familial prostate cancer: Similarly, TIMP3 is suppressed in prostate cancer cells by EZH2 which promoted the degradation of the extracellular matrix (ECM) and metastasis [29], TIMP3 was a potential target in VCaP, VCaP-DHT, abl and LNCaP cell lines and negatively correlated with EZH2 (Coef= -0.52, P<0.05) in prostate cancer in our analysis (Supplementary Tables S1 and S3).