CDKN2A and Familial prostate cancer: In fact, CDKN2A, ADRB2, CDH1 [4, 30] and SLIT2 [31] were reported to be suppressed by EZH2 in prostate cancer cells and were also targeted by EZH2 in at least one prostate cell line in our ChIP sequencing analysis (Supplementary Table S1).