IGFBP5 and breast cancer: A recent GWAS study [25] from Ghoussaini M et al. demonstrated that the variant rs4442975, which is strongly correlated with rs13387042 [26, 27] (r2>0.8), and disrupts the recruitment of FOXA1 [25, 28], was associated with elevated BC risk in Europeans due to a resulting reduction in IGFBP5 expression.