The results of the present study showed that basal Snail, Slug and E-cadherin expression was not affected by SPRY2 overexpression in two human ovarian cancer cell lines, SKOV3 and OVCAR5, while the AREG-induced up-regulation of Snail, down-regulation of E-cadherin and increase in cell invasion were attenuated by SPRY2 overexpression. Here, SPRY2 is linked to ovarian cancer.