In HeLa, human hepatocellular carcinoma, neuroblastoma, and CREF cells, overexpression of AEG-1 increased the matrix invasion and in vivo studies using nude mice xenograft models of human hepatocellular cells showed that the overexpression of AEG-1 resulted in highly aggressive and metastatic tumors [16–19]. Here, MTDH is linked to metastatic neoplasm.