In this study, we evaluated the effect on the splicing mechanism of five different intronic variations, found in three genes (SCN5A, MYBPC3, and ACTC1) of five patients/families, and probably implicated in the triggering of two inherited cardiomyopathies: Brugada syndrome (BrS) and hypertrophic cardiomyopathy (HCM). This evidence concerns the gene SCN5A and cardiomyopathy.