Actually, the activation of STAT3 is due to the phosphorylation of the tyrosine 705 site, which proximal C, STAT3 binds to STAT3-specific DNA binding elements and upregulates various STAT3 downstream target genes among them, VEGF was an important one [32] ,which create conditions for tumor invasion and metastasis. The gene discussed is VEGFA; the disease is neoplasm.