Although the majority of p53 residues subjected to PTM are infrequently mutated in human tumors, and although none of the PTM sites found in the p53 DBD represents a hotspot for tumor mutations, the codons for Lys132, Thr155, Ser215, Glu258, Asp259, and Cys277 were shown to have at least 90 cancer-associated mutations each [216]. This evidence concerns the gene TP53 and cancer.