Analysis of several cancer cell lines harboring mutated forms of p53, such as ovarian TOV cells possessing the Arg175His p53 mutation, pancreatic cancer PANC1 cells with the Arg280Thr mutation, breast carcinoma MDA-MB-231 cells with the Arg280Lys p53 mutation, T47D cells with Lys194Phe, and BT20 cells with Lys132Gln, revealed that the glucose restriction induces acetylation of C-terminally located lysines in the mutated but not in the wild-type p53, suggesting that regulation of the autophagic process in response to starvation is lost in tumor cells [254]. The gene discussed is TP53; the disease is breast carcinoma.