In a study conducted to evaluate the influence of the RES in the accumulation of HIF-1α and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells induced by hypoxia condition, it was observed that resveratrol was able to reduce the accumulation of HIF-1α and the expression of VEGF through inhibition of Akt and p42 and p44 MAPK phosphorylation [82]. This evidence concerns the gene VEGFA and hepatocellular carcinoma.