PRKAA1 and cancer: Specifically related to cancer, several studies have shown that deregulation of several protein kinases, including MAPK, Raf kinase, Akt, mTOR, MLK3, Src kinase, AMPK and protein kinase D are associated to a variety of cancers, such breast, gastric, thyroid, prostate, lung, liver and colorectal cancer [66,67,68,69,70,71,72,73,74].