These include NSD2/ Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) in Wolf-Hirschhorn syndrome, NSD3 in cancer, euchromatin histone methyl transferase1 (EHMT1) in the 9q subtelomeric deletion syndrome and enhancer of zeste, drosophilahomolog 2 (EZH2) in Weaver syndrome [72,73,74,75]. The gene discussed is NSD3; the disease is cancer.