AXL was recently identified as a direct transcriptional target of HIF-1 and HIF-2 in tumor cells where it mediates the prometastatic behavior of HIF signaling in von Hippel Lindau (VHL)-deficient renal cell carcinoma and hypoxic hepatocellular carcinoma cells [41]. The gene discussed is AXL; the disease is hereditary clear cell renal cell carcinoma.