It is suggested that in the pathogenesis of PAD in patients suffering from diabetes, a significant role is played by pro-inflammatory cytokines and acute-phase proteins; the mentioned elements include interleukin-6 (IL-6), tumor necrosis factor (TNF)-alpha, C-reactive protein (CRP), and fibrinogen [4,6,10,11]. The gene discussed is IL6; the disease is peripheral arterial disease.