NFE2L2 and diabetes mellitus: Studies in our laboratory have previously shown that genetically-induced antioxidant pathways, such as metallothionein (MT) or Nrf 2 (nuclear factor erythroid-related factor 2) overexpression, or pharmacological induction of these pathways by zinc administration (to induce MT) or sulforaphane (to induce Nrf2) alleviate DM-induced cardiac inflammation oxidative stress and fibrosis [2,84,85,86,87,88,89].