In addition, other studies have reported lower circulating levels of IL-6 in CC homozygous patients with different types of cancer, arthritis, cirrhosis, pancreatitis, retinal idiopathic Eales’s vasculitis, surgical coronary revascularization and end-stage renal disease on hemodialysis [12,13,14,15,16,17,18]. This evidence concerns the gene IL6 and arthritic joint disease.