MERTK and AXL have been implicated in numerous hematopoietic malignancies, including acute leukemias (AML and acute lymphoblastic leukemia—ALL), chronic leukemias (chronic myeloid leukemia—CML and chronic lymphocytic leukemia—CLL), and multiple myeloma (MM). This evidence concerns the gene AXL and B-cell chronic lymphocytic leukemia.