ASP2215 has an IC50 of 0.7 nM against AXL [93] and 0.29 nM against FLT3 [102] in enzymatic assays, potently inhibits phosphorylation of FLT3 in a FLT3-ITD+ AML cell line, and prolongs survival in orthotopic xenograft models of FLT3-ITD+ AML. Here, FLT3 is linked to acute myeloid leukemia.