ERK1/2 and AKT are known to modulate anti-apoptotic signaling in cancer [51,52], and shRNA-mediated knockdown of MERTK in ALL cell lines decreased expression of genes encoding pro-survival proteins BCL2L1 (BCL-XL), PIK3R5 (phosphotidylinositol 3 kinase—PI3K), and PRKCB (protein kinase C—PKC). Here, AKT1 is linked to acute lymphoblastic leukemia.