Furthermore, it has been reported that the administration of Tranilast, an anti-fibrotic agent, in murine models using E-G7 lymphoma, LLC1 Lewis lung cancer, or B16F1 melanoma cells resulted in an evident decrease of Treg and myeloid-derived suppressor cells (MDSC), associated with a decrease of stromal cell-derived factor-1 (SDF-1), PGE2, and TGF-β. The gene discussed is CXCL12; the disease is melanoma.