FOXP3 and rheumatoid arthritis: Although RA male patients harboring the allele A of rs3761548 in FOXP3 will also display defective Treg numbers and functions due to lower FOXP3 transcription, these Treg alterations will be counterbalanced by higher miR-221, miR-222 and miR-532 expression levels that will lead to reduced cell proliferation and inflammation compared to RA women.