Several single-nucleotide polymorphisms (SNPs) of SHIP2 are involved in metabolic syndrome (Kaisaki et al., 2004; Kagawa et al., 2005); thus, it will be very interesting to evaluate the effect of these SHIP2 SNPs on AD pathogenesis in our FcγRIIb-SHIP2 axis. Here, FCGR2B is linked to Alzheimer disease.