INPPL1 and Alzheimer disease: Because oligomeric Aβ decreases PtdIns(4,5)P2 levels in AD (Berman et al., 2008), as we also observed, there is a possibility that SHIP2 activation together with either Synj1 upregulation or PTEN downregulation induces the imbalance in the phosphoinositide pool between PtdIns(3,4)P2 and PtdIns(4,5)P2, and leads to AD pathogenesis.