Despite tremendous efforts showing that Aβ plays a central role in the pathogenesis of AD, including memory impairment, synaptic loss, and neuronal cell death (Cleary et al., 2005; LaFerla et al., 2007), mechanistic understanding of tau phosphorylation in Aβ-induced memory deficits remains poor (Rapoport et al., 2002; Roberson et al., 2007; Shipton et al., 2011). Here, MAPT is linked to Alzheimer disease.