TGFB1 and asthma: However, it should be stated that in a study examining the effect of anti-IL-5 in bronchial biopsies from 24 atopic asthmatics, it was demonstrated that apart from the reduction in the numbers and the percentage of airway eosinophils expressing mRNA for TGF-β1 (which has been implicated in asthma remodelling), anti-IL-5 was associated with reduction in the expression of tenascin, lumican and procollagen III in the bronchial mucosa RBM as well as with reduction of TGF-β1 concentration in bronchoalveolar lavage (BAL) (73).