For example, the dysregulation of TFEC, which belongs to the micropthalmia family of TFs, leads to renal cell carcinoma [33], RUNX1 upregulation is an important factor for clear cell renal carcinoma survival [1, 34], and ZNF395 is known to play a role in the pathogenesis of clear cell renal carcinoma [24], possibly affecting kidney cancer patient survival (Additional file 1: Figure S9). Here, RUNX1 is linked to hereditary clear cell renal cell carcinoma.