The ZNF395 gene is located at 8p21, and TENET identified hypomethylation of enhancer probe cg12116192 (located ~500 kb from the TSS of ZNF395) to be positively associated with the expression of the ZNF395 gene (Fig. 8a, b), suggesting that hypomethylation of this probe may be responsible for the increased expression of ZNF395 in kidney tumors. This evidence concerns the gene ZNF395 and kidney neoplasm.