Upon independent knockdown of these genes in C42B prostate cancer cells, we found that for HOXC6, the top GO terms for downregulated genes were mitotic cell cycle and cell cycle (e.g., CDKN2C, CDK16, IGFBP3), and for DLX1, genes involved in proliferation and androgen-responsive genes were enriched in downregulated genes (e.g., CDCA7, MAGOH, MAD2L1). This evidence concerns the gene CDK16 and Familial prostate cancer.