Although we did not test other adhesion molecules involved in NK cell recognition like LFA-3, we have previously shown that blocking ICAM-1/LFA-1 interaction almost completely eliminate NK cell cytotoxicity in hematological cancer cells (including B-CLL) [(55) and data not shown] suggesting a minor role for other adhesion molecules. This evidence concerns the gene CD58 and hematopoietic and lymphoid cell neoplasm.