Moreover, the pattern of expression of the different ERβ isoforms was similar in BLM (NRAS-mutant, BRAF-wild type) and WM115 (BRAF V600D-mutant) melanoma cells: ERβ1 and ERβ5 were found to be expressed at similar levels while ERβ2 showed a higher level of expression. Here, ESR2 is linked to melanoma.