EGFR and glioblastoma: In addition, oncogenic somatic mutations in specific sites of the EGFR gene, such as EGFR variant III (EGFRvIII) in glioblastoma multiforme (GBM) and activating EGFR mutations in non-small cell lung cancer (NSCLC), have been reported to be closely associated with tumorigenesis (Guo et al., 2015; Tan et al., 2015).