TP53 and Alzheimer disease: In addition, GA can also inhibit the SUMOylation of p53 (Fukuda et al., 2009), which is known to play a crucial role in the early phase of LTP (Pustylnyak et al., 2015) and has been shown to be involved in aging and AD (LaFerla et al., 1996; Lanni et al., 2012).