TRPC1 and hypertrophy: Recent studies using TRPC3-deficient C57BL/6 J mice have shown that selective inhibition of TRPC3 does not mitigate the LV hypertrophy induced by pressure overload, though deletion of multiple TRPC channels, including TRPC3/C6 and TRPC1/C4, suppresses LV hypertrophy in mice8, 11.