To our surprise, runx1-GFP+ cells did not show an obvious increase in the CHT after challenge by 5–10 × 103 cfu E. coli (Fig. 3A–C), even when the myeloid progenitors were drastically expanded (Fig. 2H; see supplemental Figure S2A), suggesting distinct reactions of HSPCs and myeloid progenitors upon infection. The gene discussed is RUNX1; the disease is infection.