RIOX2 and Miyoshi myopathy: Strikingly, physical binding between mdig and c-myc was detected by mass-spectrometry in NCI-H929 cells (Fig. 4B), which was further validated by co-IP assay in both NCI-H929 and MM1S cells (Fig. 4C), implying that mdig might be assembled into functional protein complexes together with c-myc and directly participate in c-myc-induced oncogenesis for the development of MM.