Given that our current findings have clearly demonstrated a regulatory circuit among c-myc, mdig and IL-6 signaling, it is plausible to speculate that mdig may be assembled into protein complexes with chromatin- or DNA-binding protein(s), like c-myc, and be recruited to MM-specific signature genes, including GP130, and exerts its regulatory functions on gene expression. This evidence concerns the gene RIOX2 and Miyoshi myopathy.