After binding to its receptor (IL-6R) and recruiting signal transducer, GP130 (also known as CD130 or IL-6ST), IL-6 can activate Janus Kinase (JAK)/signal transducer and activator of transcription 3 (STAT3), Akt and mitogen-activated protein kinase (MAPK) pathways to promote proliferation, survival and drug resistance of the MM cells8. This evidence concerns the gene IL6ST and Miyoshi myopathy.