DACT1 methylation was associated with advanced tumor size grade (P < 0.05), lymph node metastasis (P < 0.05) and distant metastasis (P = 0.05) respectively, but was not associated with the clinicopathological characteristics of patients with gastric cancer including age, gender, H. pylori infection, Lauren classification and tumor differentiation. Here, DACT1 is linked to neoplasm.