Researchers has found that KRT19 was involving in tumor cell proliferation and invasion promotion not only in HCC, but also in CCA in a Caucasian series of 242 consecutive HCC samples in comparison with other biliary/HPC markers, epithelial cell adhesion molecule (EpCAM) and α-fetoprotein (AFP) revealed [9–11]. The gene discussed is AFP; the disease is hepatocellular carcinoma.