However, GRK2 downmodulation has been described to be beneficial in other types of cardiac hypertrophy, such as after thoracic aortic constriction, in genetically-based mice models of cardiac dysfunction and after myocardial infarction [35–37], whereas high GRK2 levels correlate well with the degree of heart hypertrophy in different human and murine conditions [16, 37, 38]. This evidence concerns the gene GRK2 and cardiac hypertrophy.