The effect of the interaction between TNF-α inhibitors and statins on the various lipid parameters after adjustment for hyperlipidemia, hypertension, obesity, gender, and age reached statistical significance for LDL (p < 0.01), TC (p = 0.02), and TG (p < 0.01) values (Table 4). This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.