Taken together, our results, for the first time, illustrated the miR-199a-3p-YAP1-Jagged1-Notch signaling in HCC, in which miR-199a-3p targets YAP1 and regulates the Jagged1-Notch signaling to inhibit the tumorigenesis of HCC. This evidence concerns the gene YAP1 and hepatocellular carcinoma.