To conclude, despite the increasing data about the possible role of L1CAM as a strong prognostic factor of poor outcome in many cancers, including endometrial and ovarian cancer as well as the promising data concerning the possibility of detection of L1CAM soluble forms in sera of cancer patients, we did not find evidence for sL1CAM feasibility as a marker of endometrial or ovarian cancers. Here, L1CAM is linked to cancer.