TH1 cells are ascribed with anti-cancer functions, notably because these cells secrete high levels of IFN-γ, which prevents tumor angiogenesis, enhances tumor cell immunogenicity by upregulating MHC class I and II expression, promotes recruitment of immune cells including CD8 T and NK cells that mediate tumor-killing activity, and increases the anti-tumor activity of macrophages [4–6]. The gene discussed is CD8A; the disease is cancer.