A previous study reported that the carriage of IL-1 polymorphisms was significantly associated with H. pylori-related gastric inflammation, atrophy, and carcinogenesis [13], and we have recently found that H. pylori-infected patients with IL-1 polymorphisms were correlated with an increased level of inflammation and increased risk of myocardial infarction [14], and smoking patients with H. pylori infection and IL-1 polymorphisms had significantly increased risk of cardiovascular events after acute coronary syndrome (ACS) [15]. The gene discussed is IL1B; the disease is acute coronary syndrome.