The C-statistic of the conventional risk factors (age, male sex, diabetes, hypertension, dyslipidemia, obesity, current smoking, and family history) was 0.68 (95% CI, 0.60–0.75; P<0.001) and that after adding H. pylori infection and IL-1 polymorphisms was 0.70 (95% CI, 0.63–0.77; P<0.001). The gene discussed is IL1B; the disease is diabetes mellitus.