Due to the emerging role of RhoGDI’s proteins, RhoGDI1 and RhoGDI2, in many types of cancers [17, 20, 21, 36–38] and given the frequency with which those molecules expression is regulated in cancer, it is comprehensible that RhoGDI’s proteins have crucial roles in the carcinogenic process. This evidence concerns the gene ARHGDIB and cancer.