The RhoB is one of the downregulated GTPases in breast cancer [24] and invasive carcinomas of the head and neck [45]; accordingly, we found a decreased RhoB protein expression in the pancreatic cancer cell lines BxPC3 and PANC-1, as compared to non-cancerous pancreatic cell line hTERT-HPNE. Here, RHOB is linked to familial pancreatic carcinoma.