There are many reports about the overexpression or downregulation of RhoGDI1 and RhoGDI2 proteins in many types of cancers, with contrasting results [17, 20, 24, 28–31], but there is a lack of information about the expression of RhoGDI3 in pancreatic cancer. The gene discussed is ARHGDIG; the disease is familial pancreatic carcinoma.