Since Egr1 is known to be involved in cardiac hypertrophy [111] and cardioprotection [112] in addition to angiogenesis in the heart [121], the difference in expression patterns may reflect distinct roles in different cell types (e.g. angiogenesis in endothelial cells and hypertrophy/cardioprotection in cardiomyocytes) in the heart. Here, EGR1 is linked to cardiac hypertrophy.