Interestingly, treatment with RANKL in combination with TRAMP-C1 tumor cell-derived exosomes for 96 hours resulted in a statistically significant impairment of RANKL-induced osteoclastic differentiation of RAW264.7 cells treated with the higher concentration of exosomes (50 ng/103 seeded cells; Fig 2B and 2C). Here, TNFSF11 is linked to neoplasm.