We built a latent class model based on the following cardiovascular risk factors, and diseases; age, men, European ancestry, BMI, diastolic blood pressure, heart rate, antihypertensive therapy, previous myocardial infarction, heart failure, diabetes, prior stroke, peripheral artery disease, smoking, alcohol use, hypercholesterolemia, PR-interval duration, glomerular filtration rate, urinary albumin excretion, and incident AF. The gene discussed is ALB; the disease is atrial fibrillation.