In contrast, ORM-10962 failed to reduce the arrhythmia incidence during ischaemia-reperfusion in rat in vivo (Fig 12A) and in guinea-pig in vitro (Fig 12B), even though several papers claimed the efficiency of NCX inhibition during ischaemia-reperfusion [15,40,41,42,43]. The gene discussed is TLX2; the disease is cardiac arrhythmia.