Of our 40 DMRs that were carried forward for replication, three CpGs reached significant p-values in the replication sample and included MDH2, CLEC3B, and HSPB6. While, to the best of our knowledge, none of them have previously been related to pain perception or expression, a recent comparative analysis of gene expression in tendinopathy found evidence of CLEC3B (and COL1A2) upregulation in tendon cells in response to cyclic strain [42]. The gene discussed is MDH2; the disease is disease of the tendon.