Each pathway category refers to various single KEGG pathways (from a total of 15): HIF1 (mTOR/hsa04150, Pathways in cancer/hsa05200, Renal cell carcinoma/hsa05211), p53 (hsa04115), RB (Cell cycle/hsa04110), Apoptosis (Apoptosis/hsa04210), GLI (Hedgehog/hsa04340), APC (Wnt/hsa04310), RTK (ErbB/hsa04012, Pathways in cancer/hsa05200), SMAD (TGF-β/hsa04350) and PI3K (ErbB/hsa04012, Pathways in cancer/hsa05200, mTOR/hsa04150, MAPK/hsa04010, Insulin/hsa04910, Focal adhesion/hsa04510, Chenokine/hsa04062, VEGF/hsa04370). The gene discussed is TGFB1; the disease is hereditary clear cell renal cell carcinoma.