Moreover, the recent review suggested that metabolic switch of solid tumors toward glycolysis resulted from environmental selection, which was positively related to cell survival.38 Samudio et al.39, 40 found that the coculture of leukemia cells with MSCs increased the Warburg effect (pro-glycolysis) by upregulating the expression of uncoupling protein 2, which was known to uncouple oxidative phosphorylation and thus reduced mitochondrial ROS generation in leukemia cells. The gene discussed is UCP2; the disease is leukemia.