DNM1L and acute lymphoblastic leukemia: Here, we report that: (i) the pro-survival effects of direct coculture with MSCs are more superior to those in Transwell models; (ii) MAPK/ERK signaling pathway is remarkably activated in T-ALL cells cocultured with MSCs; and (iii) this signaling pathway promotes the phosphorylation of Drp1 at S616 and alters mitochondrial metabolism.