This was caused by a remarkable elevation of the activating phosphorylation of Drp1 at S616, which is a key mediating event in mitochondrial fission.27, 41 T-ALL cells overexpressing wild-type Drp1 or Drp1 S616E exhibited fragmented mitochondria, decreased mitochondrial ROS levels, a pro-glycolytic metabolism shift and increased drug resistance. Here, DNM1L is linked to acute lymphoblastic leukemia.