Finally, we investigated the chemoresistance of T-ALL cells expressing Drp1 S616E or Drp1 S616A, and found that Drp1 S616E prevented apoptosis, whereas Drp1 S616A promoted the cytotoxicity of Ara-c/MTX (Figures 5e and f). This evidence concerns the gene DNM1L and acute lymphoblastic leukemia.